Mitochondrial Dysfunction in Neural Injury

Mitochondrial Dysfunction in Nervous System Injury

P12: Mitochondrial Dysfunction and Oxidative Stress in Epilepsy

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P8: Temporal Lobe Epilepsy and Mitochondrial Dysfunction

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Burn injury causes mitochondrial dysfunction in skeletal muscle.

Severe burn trauma is generally followed by a catabolic response that leads to muscle wasting and weakness affecting skeletal musculature. Here, we perform whole-genome expression and in vivo NMR spectroscopy studies to define respectively the full set of burn-induced changes in skeletal muscle gene expression and the role of mitochondria in the altered energy expenditure exhibited by burn pati...

Mitochondrial dysfunction early after traumatic brain injury in immature rats.

Mitochondria play central roles in acute brain injury; however, little is known about mitochondrial function following traumatic brain injury (TBI) to the immature brain. We hypothesized that TBI would cause mitochondrial dysfunction early (<4 h) after injury. Immature rats underwent controlled cortical impact (CCI) or sham injury to the left cortex, and mitochondria were isolated from both hem...